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KMID : 0614019990150010320
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Journal of Pharmaceutical Sciences (C.N.U.)
1999 Volume.15 No. 1 p.320 ~ p.332
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Pharmacological Actions of New Wonbang Woohwangchungsimwon Liquid on Cardiovascular System
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Cho Tai-Soon
Lee Sun-Mee
Kim Nak-Doo
Hur In-Hoe
Ann Hyoung-Soo
Kwon Kwang-II
Park Seok-Ki
Shim Sang-Ho
Shin Dae-Hee
Park Dai-Kyu
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Abstract
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In order to investigate the pharmacological properties of New Wonbang Woohwangchungsimwon Liquid (NSCL), effects of Wonbang Woohwangchungsimwon Liquid (SCL) and NSCL were compared. In isolated rat aorta, NSCL and SCL showed the relaxation of blood vessels in maximum contractile response to phenylephrine (10^-6M) regardless to intact endothelium or denuded rings of the rat aorta. Furthermore, the presences of the inhibitor of NO synthase and guanylate cyclase did not affect the relaxing effect of NSCL and SCL. NSCL and SCL inhibited the vascular contractions induced by acetylcholine, prostaglandin endoperoxide or peroxide in a dose-dependent manner. In conscious spontaneously hypertensive rats (SHRs), NSCL and SCL significantly decreased heart rate. NSCL and SCL, at high doses, had a negative inotropic effect that was a decrease of left ventricular developed pressure and (-dp/dt)/(+dp/dt) in the isolated perfused rat hearts, and also decreased the contractile force and heart rate in the isolated rat right atria. In excised guinea-pig papillary muscle, NSCL and SCL had no effects on parameters of action potential such as resting membrane potential, action potential amplitude, APD_90 and V_max at low doses, whereas inhibited the cardiac contractility at high doses. These results suggested that NSCL and SCL have weak cardiovascular effects with relaxation of blood vessels and decrease of heart rate, and that this effect is no significant differences between cardiovascular effects of two preparations.
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KEYWORD
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New Wonbang Woohwangchungsimwon Liquid, Wonbang Woohwangchungsimwon Liquid, cardiovascular system, SHR, negative inotropic effect, action potential
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